Category Archives: Tenofovir

  1. Acceptability of coitally-associated versus daily use of 1% tenofovir vaginal gel among women in Pune, India

    via International Health, by Sanjay Mehendale, Swapna Deshpande, Rewa Kohli, Sharon Tsui, Elizabeth Tolley Abstract This study reports on the acceptability of 1% tenofovir microbicide gel among participants randomised to the coitally-associated use (n=50) or daily use (n=50) arms of a Phase II clinical trial in Pune, India. In a 6-month follow-up study, information on behavioural domains Read More >>

    behavioral research, India, Microbicides, Tenofovir, vaginal microbicide, women
  2. IRMA Statement on Discontinuation of Gel Arm in VOICE Prevention Trial

    25 November, 2011IRMA Expresses Disappointment; Calls for MTN 017 to Move Forward International Rectal Microbicide Advocates (IRMA) expresses disappointment regarding today’s announcement that the vaginal tenofovir gel arm in the Microbicide Trial Network’s (MTN) VOICE trial is being discontinued. VOICE has been exploring two ARV-based HIV prevention approaches since it began enrolling women in high incidence areas Read More >>

    Microbicide Trials Network, MTN, MTN 017, rectal microbicide, Tenofovir, vaginal microbicide, VOICE
  3. ARV gel almost ready to roll out

    via the Daily News, by Liz Clarke In the time it takes parents to see their children grow from birth to adulthood, the vaginal gel containing the antiretroviral tenofovir has been under close and intense scrutiny. Now nobody is more keen to see the fast-track roll-out of the life-saving microbicide than Professor Quarraisha Abdool Karim. Research initiated Read More >>

    CAPRISA, Microbicides, Salim S. Abdool Karim, South Africa, Tenofovir, vaginal microbicide, WHO
  4. NIH researchers show how anti-HIV drug acts to block herpes virus

    via Infotech “The findings explain the results of a recent clinical trial showing that the anti-HIV drug tenofovir, when it is formulated as a vaginal gel, could reduce the risk of herpes simplex virus (HSV) infections — as well as HIV infections — in women. Tenofovir taken orally had been demonstrated to inhibit reproduction of HIV, but Read More >>

    herpes, HIV, HPV, Microbicides, Tenofovir, vaginal microbicide, women
  5. Optimal Rectal Microbicide Design

    via AIDS: Official Journal of the International AIDS Society, by Herrera, Carolinaa; Cranage, Martina; McGowan, Ian; Anton, Peter; Shattock, Robin J Objective Receptive anal intercourse in both men and women is associated with the highest probability for sexual acquisition of HIV infection. As part of a strategy to develop an effective rectal microbicide, we performed an ex-vivo Read More >>

    anal intercourse, Microbicides, rectal microbicide, Tenofovir
  6. The Pharmacokinetics of Tenofovir Following Intravaginal and Intrarectal Administration of Tenofovir Gel to Rhesus Macaques

    via AAC Accepts, by Jeremy Nuttall, Angela Kashuba, Ruili Wang, Nicole White, Philip Allen, Jeffrey Roberts, and Joseph RomanoAbstract Tenofovir gel (1%) is being developed as a microbicide for the prevention of HIV infection, and has been shown to reduce transmission to women by 39%. The gel also prevents infection in macaques when applied intravaginally or intrarectally Read More >>

    Microbicides, rectal microbicide, rectal transmission, Tenofovir, vaginal microbicide
  7. Microbicide Trials Network Statement on Decision to Discontinue Use of Oral Tenofovir Tablets in VOICE, a Major HIV Prevention Study in Women

    via Microbicide Trials Network VOICE, an HIV prevention trial evaluating two antiretroviral (ARV)-based approaches for preventing the sexual transmission of HIV in women – daily use of one of two different ARV tablets or of a vaginal gel – will be dropping one of the oral tablets from the study. The decision to discontinue use of tenofovir Read More >>

    Africa, Microbicide Trials Network, PrEP, South Africa, Tenofovir, Truvada, Uganda, women, Zimbabwe
  8. New, Long-Term PrEP Study Announced

    Via Now Chelsea, by Sam Spokony. Few methods of HIV prevention have been as promising, or as controversial, as pre-exposure prophylaxis (PrEP). After a history of underground practice and off-label prescriptions, the approach has recently begun to receive serious attention from researchers, policy makers and health care advocates. An outgrowth of post-exposure prophylaxis (or PEP, a short-term Read More >>

    clinical trials, FTC, HIV/AIDS, iPrEx, maraviroc, new prevention technologies, pre-exposure prophylaxis, PrEP, prevention, Selzentry, study, Tenofovir, Treatment as Prevention, Truvada
  9. Microbicide Trials Network Statement On The Partners PrEP Study And The CDC’s TDF2 Study: VOICE Study Will Continue

    Via Medical News Today. Researchers from two major HIV prevention trials announced favorable results of an approach called oral pre-exposure prophylaxis, or PrEP. One of these trials, the Partners PrEP Study, has provided the strongest evidence yet of PrEP’s effectiveness. Information from both studies will need to be fully evaluated before it can be determined what impact Read More >>

    ARV, ARVs, HIV, HIV transmission, Microbicides, new prevention technologies, PrEP, prevention, rectal microbicide, Tenofovir, Truvada, vaginal microbicide
  10. PrEP Media Round-Up – It Works for Heterosexuals Too!

    [UPDATED JULY 18] The exciting news was announced last week that pre-exposure prophylaxis has been shown to work for heterosexual men and women as well as MSM. This is HUGE for HIV prevention. Below is a selection of news items and press releases we have collected on the two studies that reported out last week. In the comments feel Read More >>

    Africa, Gilead, heterosexual epidemic, HIV, HIV transmission, HIV/AIDS, HIV/AIDS policy, iPrEx, new prevention technologies, Partners PrEP, PrEP, prevention, Tenofovir, Truvada